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  • ,
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    ' ? 1891 . . . , ', ( " - "), :
    -H2O
    H2N-CH2-C = O + HNHCH2COOH -

    OH
    H2N-CH2- CO-NH -CH2-COOH
    ( ')

    ' ', , ' ', ( ).
    . . Գ .
    , , , , .
    -CO-NH- .
    , , ,  :

    H2N-CH2-CO-NH-CH (CH3)-COOH
    (H---OH)
    NH2-CH (CH3)-CO-NH-NH2-CO-NH-CH2-COOH
    (H----OH)
    - -, , ,
    , ' ', : ) () , ; ) '; ) . '.
    :


    -HCl
    R-COCl + H2N-CH-COOH - R-CO-NH-CH-COOH
    | |
    CH2 CH3

    :
    -HOH
    H2N-CH2-COOH + HOR - H2N-CH2-COOR
    ' N-, , (䳳, ):
    -H2O
    R-CO-NH-CH-COOH + HNHCH2-COOR -
    |
    CH3
    R-CO-NH-CH-CO-NH-CH2-COOR ----
    |
    CH3
    H2N-CH-CO-NH-CH2-COOH
    |
    CH3
    , '. -, -, .
    ' 1960 . (). . - , -CH2Cl (1- ), "" ', : (1)-NaCl
    -CH2Cl + NaOOC-CHR-NHCOR'--CH2O-C-CHR-NHCOR '-CH2O-C-CHR-
    | | | |
    O O
    + HOOC-CHR''-NHOR (3)
    -NH2 ----------- -CH2O-C-CHR-
    | |
    (4) O
    -NHCO-CHR''-NHCOR '-CH2O-C-CHR - NHCO-CHR''-NH2 . . | |
    O
    , . , NH2 - (2- ). , ' (3- ). (4- ), . ϳ "" ' :
    HBr
    -CH2O-CO-CHR-NH ... CO-CHR'NH2 ---
    -CH2OH + HOOCCHRNH ... COCHR'NH2

    , . , (51 ) (124 ) , . , 1968 . , 369 .
    . 111





















         
     
         
     
     
     

     

     

     

     

     

     

     
     
     
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